Research and Development Services
Our laboratory can provide options for College of American Pathologists (CAP), Clinical Laboratory Improvements Amendments (CLIA), or research and development (R&D) level documented reports. GENETWORx supports clinical and pharmaceutical assay development on a wide variety of genetic platforms.
Unsurpassed Support
- Single Nucleotide Polymorphism (SNP) Genotyping using real-time PCR – GENETWORx uses the 7500 Real-time PCR System for the development of companion diagnostic SNP assays, performing the bioinformatics, assay design and validation of custom assays
- Multiplex SNP assay development (Luminex bead-based chemistry) – GENETWORx can prepare custom multiplex assays for SNP genotyping or pathogen detection using bead-based assays analyzed using the Luminex LX200 platform
- Sanger Sequencing – GENETWORx uses the high-throughput 3500xl genetic analyzer for DNA sequencing by Applied Biosystems Big Dye™ Chemistry
- Mutation confirmation
- Plasmid sequencing
- Viral genomes
- Amplicon sequencing
- Next Generation Sequencing
- Tumor sample analysis
- Microbial identification
- Methylation studies
- Exon sequencing
- Pharmacogenomics – Cytochrome P450 (CYP) genotyping
- STR Genotyping
- Confirmation of cell line identity
- Loss of Heterozygosity (LOH) Studies
Research and Development Specialties
- Companion Diagnostics – Development and analytical validation of molecular diagnostic markers to accompany medication development studies
- Clinical Trial Support
- Mutation detection or SNP genotyping to support clinical trials
- DNA sequencing to confirm gene therapy targets
- CYP450 genotyping to correlate medication metabolism with medication efficacy and response