Research and Development Services

Our laboratory can provide options for College of American Pathologists (CAP), Clinical Laboratory Improvements Amendments (CLIA), or research and development (R&D) level documented reports. GENETWORx supports clinical and pharmaceutical assay development on a wide variety of genetic platforms.

Platforms and Technologies

  • Single Nucleotide Polymorphism (SNP) Genotyping using real-time PCR – GENETWORx uses the 7500 Real-time PCR System for the development of companion diagnostic SNP assays, performing the bioinformatics, assay design and validation of custom assays
  • Multiplex SNP assay development (Luminex bead-based chemistry) – GENETWORx can prepare custom multiplex assays for SNP genotyping or pathogen detection using bead-based assays analyzed using the Luminex LX200 platform
  • Sanger Sequencing – GENETWORx uses the high-throughput 3500xl genetic analyzer for DNA sequencing by Applied Biosystems Big Dye™ Chemistry
    • Mutation confirmation
    • Plasmid sequencing
    • Viral genomes
    • Amplicon sequencing
  • Next Generation Sequencing
    • Tumor sample analysis
    • Microbial identification
    • Methylation studies
    • Exon sequencing
  • Pharmacogenetics – Cytochrome P450 (CYP) genotyping
  • STR Genotyping
    • Confirmation of cell line identity
    • Loss of Heterozygosity (LOH) Studies

Research and Development Specialties

  • Companion Diagnostics – Development and analytical validation of molecular diagnostic markers to accompany drug development studies
  • Clinical Trial Support
    • Mutation detection or SNP genotyping to support clinical trials
    • DNA sequencing to confirm gene therapy targets
    • CYP450 genotyping to correlate drug metabolism with drug efficacy and response
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