A Healthcare Cost Savings Program with proven roi
Medication management is a personalized approach that is proven to reduce healthcare costs for employers
A Healthcare Cost Savings Program with proven roi
Medication management is a personalized approach that is proven to reduce healthcare costs for employers
A small group of individuals represent a high percentage of healthcare costs. [1]
20% of Individuals
account for 81% of Healthcare Spend
Providing Medication Management for those who need it most can
Reduce Healthcare Costs & Poor Health Outcomes
WRONG Medications Increase Healthcare Cost & Produce Poor Health Outcomes
Addressing Medication Mismanagement is proven to reduce:
Non-optimal medications directly impact healthcare cost.
By enrolling in a Medication Management Program, 5,288 Medicare Advantage members (age 65+) from January 2018 through August 2020 resulted in a:
- 14.9% decrease in inpatient visits
- 6.8% decrease in emergency department visits[4]
Provide Medication Management for high cost employees today
WRONG Medications Increase Healthcare Cost & Produce Poor Health Outcomes
Addressing Medication Mismanagement is proven to reduce:
Non-optimal medications directly impact healthcare cost.
By enrolling in a Medication Management Program, 5,288 Medicare Advantage members (age 65+) from January 2018 through August 2020 resulted in a:
- 14.9% decrease in inpatient visits
- 6.8% decrease in emergency department visits[4]
Provide Medication Management for high cost employees today
Healthcare Programs
Create a Happy & Productive Workforce.
Healthier Employees are
Happier Employees.
- Retention
- Recruitment
Healthier Employees are
Happier Employees.
- Retention
- Recruitment
Healthier Employees are
Productive Employees.
- Decreasing Absenteeism
- Reducing Presenteeism
Healthier Employees are
Productive Employees.
- Decreasing Absenteeism
- Reducing Presenteeism
How does EffectiveRX™ work?
Population Analytics
Custom ROI Analysis identifies employees who are most likely to benefit from the EffectiveRX™ Program and estimates savings.
Proven Comunication Strategy
Coordinated outreach to ensure employee education and high risk employee program enrollment.
Comprehensive Testing
Our comprehensive Pharmacogenomics panel is reviewed by a pharmacist team to provide actionable recommendations and assist in getting your employee on the RIGHT medication.
Healthcare Provider Engagement
Our PharmD team works directly with your employee's physician to adjust his/her medication regimen to reduce risk(s).
GENETWORx has partnered with Coriell Life Sciences, a leading precision medicine company, to provide EffectiveRX™. This health and wellness program provides the most comprehensive medication management solution for high-risk employees and includes testing to show how their DNA may be impacting their response to medications. EffectiveRX™ assists in achieving significant economic savings, improved health, and a reduction in healthcare resource utilization.
Many of us have been on medications that were:
Ineffective.
Caused side effects.
Didn’t yield results.
The healthcare cost associated with poor medication outcomes is measurable through avoidable healthcare, such as hospital stays and ER visits.
Your organization is most likely contributing.
Let us prove it. EffectiveRX provides real-world data to demonstrate how getting a patient on the right treatment quickly can drive down healthcare costs for your organization.
1 (866) 932-0109
Medication Management Test Panel
| GENE | Gene-Drug Interaction |
|---|---|
| F2 | Patients with the Factor ll gene Prothrombin variant may be at an increased risk of blood clot formation (thrombosis) when exposed to other risk factors such as smoking, pregnancy, obesity, oral contraceptive use, and immobility. The risk is approximately 3-10 times higher in individuals who have one copy of the genetic variant. The risk in people who carry two copies of the genetic variant is unknown. Individuals who do not have a Factor II Prothrombin mutation may still be at increased risk. Other changes in the Factor II gene that were not tested for, changes in other genes, and non-genetic factors may still increase a patient’s risk for thrombosis. PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed March 22nd, 2023. Ref: 52, 53 |
| F5 | Individuals with the Factor V Leiden gene variant may be at an increased risk of blood clot formation. This risk is approximately 2-10 times higher in individuals who have one copy of the genetic variant, and greater than 10 times higher for individuals who carry two copies of the genetic variant. Individuals who do not have the Factor V Leiden mutation may still be at increased risk. Other changes in the Factor V gene that were not tested for, changes in other genes, and non-genetic factors may still increase a patient’s risk for thrombosis. PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed March 22nd, 2023. Ref: 53, 54 |
| VKORC1 | Vitamin K epoxide complex subunit 1 (VKORC1) is the enzyme that activates Vitamin K. Mutations in VKORC1 are associated with deficiencies in vitamin-K-dependent clotting factors. A particular VKORC1 variant (-1639G>A) leads to increased sensitivity to warfarin. VKORC1 mutation accounts for 25-44% of warfarin dose variability and is typically tested for at the same time as 2C9 when warfarin is being considered. Ref: 3, 39 |
| MTHFR (both alleles) | The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. Genetic variation in this gene may influence susceptibility to occlusive vascular disease, neural tube defects, cancer. Mental Health: Patients who are homozygous mutant for MTHFR 677 (T/T) genotype may have an increased risk of early onset of schizophrenia, bipolar disorder, and increase in severity of depressive symptoms in depressive disorders. Ethnic populations studied include: African, Asian, Caucasian. Oncology/Rheumatology: Patients with AG or AA genotypes and treated for certain cancers (ex. lymphoma, osteocarcinoma, leukemia) and arthritis (ex. rheumatoid, psoriatic) may be at an increased risk of adverse effects if treated with methotrexate when compared to patients with GG genotype However, conflicting evidence has been reported. Other clinical and genetic factors may also influence risk of toxicity following methotrexate treatment. Cardiovascular: Individuals who are found to have two mutations of MTHFR may be at an increased risk for serious blood clot formation. Individuals who have only one or no copies of either genetic change in the MTHFR gene may still be at increased risk. Other changes in the MTHFR gene that were not tested for, changes in other genes, and non-genetic factors may still increase a patient’s risk for thrombosis. (CPIC Level best drug: C/ PharmGKB Level Best drug: 2A) (PharmGKB) Ref: 14, 15, 66, 68 |
| CYP3A4 | CYP3A4 Gene-drug variant associations affecting drug response/metabolism (ex. exposure, clearance) include atorvastatin, cyclosporine, oxycodone, quetiapine, simvastatin, tacrolimus. (CPIC Level best drug: C/ PharmGKB Level Best drug:1B)/ Genes-Drugs – CPIC (cpicpgx.org)/PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed November 2nd, 2022. |
| CYP3A5 | CYP3A5 Gene-drug variant associations affecting tacrolimus drug dosing requirements/metabolism. (CPIC Level best drug: A/ PharmGKB Level Best drug:1A)/ Genes-Drugs – CPIC (cpicpgx.org)/ CPIC: https://cpicpgx.org/guidelines/guideline-for-tacrolimus-and-cyp3a5/) PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed November 2nd, 2022. |
| CYP2D6 | CYP2D6 Gene-drug variant associations affecting drug response/metabolism include amitriptyline , atomoxetine, codeine , desipramine, doxepin, fluvoxamine, imipramine, metoprolol, nortriptyline, ondansetron, paroxetine ,risperidone, tamoxifen, tramadol, venlafaxine. (CPIC Level best drug: A/ PharmGKB Level Best drug:1A) PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed November 2nd, 2022. Ref: 43-48. |
| CYP2C19 | CYP2C19 Gene-drug variant associations affecting drug response/metabolism include amitriptyline, citalopram, clomipramine, clopidogrel, imipramine, lansoprazole, omeprazole, pantoprazole, sertraline, voriconazole. (CPIC Level best drug: A/ PharmGKB Level Best drug:1A) ) PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed November 2nd, 2022. Ref: 40-44. |
| CYP2C9 | CYP2C9 Gene-drug variant associations affecting drug response/metabolism include celecoxib, flurbiprofen, fosphenytoin ,ibuprofen, losartan, meloxicam, phenytoin, warfarin. (CPIC Level best drug: A/ PharmGKB Level Best drug:1A) ) PharmGKB Web site. http://Clinical Guideline Annotations (pharmgkb.org). Accessed November 2nd, 2022.Ref: 37, 38, 39 |
References for individual gene-drug interactions are available at EffectiveRX Panel References.
Real People. Real Impact.
References
MENTAL HEALTH
Time is of the Essence
6-8 Weeks
is the average time for patients taking an antidepressant to experience improvement in symptoms
40-60%
of patients do not experience improvement of symptoms within this time frame
Is your medication effective?
Effective RX is a pharmacogenomics test. Pharmacogenomics determines how your DNA directly impacts how your body processes medication.
Find the Right Treatment Quickly
40-60% of patients on an antidepressant do not experience an improvement in symptoms within the first 6-8 weeks.2 Avoid the trial and error of finding the right prescription that works best for you
Avoid Adverse Effects
Adverse effects to medications cause over 1 million ER visits annually in the US.3 You can minimize the liklihood of having an adverse affect by finding out which medications your body is less likely to efficiently process.
Prevent Negative Side Effects
With Mental Health EffectiveRX™, you can find the right medication the first time and avoid negative side effects often associated with mental health medications.
What is Pharmacogenomics?
According to the CDC, Pharmacogenomics (PGx) is an important type of Precision Medicine. Precision medicine tailors treatments to a specific patient based on genetic makeup, environment and behaviors.
PGx provides personalized medication management guidance to healthcare providers based on how an individual patient’s body responds to certain medications.
How does Pharmacogenomics work?
After taking a medication, the body needs to process, utilize and respond to it. Genetic makeup can impact the body’s ability to do this. Pharmacogenomics examines variations in a patient’s genes which can predict how his/her body will likely react to a medication. The information assists health care providers in selecting the most effective medication for that specific patient.
There are two important factors that can be genetically examined to determine how a patient may react to a medication:
Proteins on the surface of a cell are called “receptors.” The study of how DNA impacts these receptors is called “Pharmacodynamics.” Drugs attach themselves to the cells via these receptors. The number and type of receptors of a cell can be influenced by an individual’s DNA.
Pharmacokinetics examines the body’s ability to absorb, distribute, metaboilze and excrete a medication over a length of time.
For example, some medications must be absorbed into specific cells and tissue in order to properly process them. This is known as “drug uptake.” The breadown of a medication is called “elimination.” A decreased ability to breakdown a drug efficiently can result in a build up of the drug, causing adverse effects and bad reactions. An increase can result in the drug being processed before it has time to take effect. A patient’s DNA can impact how quickly or slowly some drugs are broken down in the body.
Save your company money every year by insuring the most effective medications through EffectiveRX™.
Are you currently taking or considering taking any of these medications? *
Psychiatric
- Abilify (Aripiprazole)
- Anafranil (Clomipramine)
- Celexa (Citalopram)
- Cymbalta (Duloxetine)
- Effexor (Venlafaxine)
- Elavil (Amitriptyline)
- Fanapt (Iloperidone)
- Lexapro (Escitalopram)
- Luvox (fluvoxamine)
- Norpramin (Desipramine)
- Orap (Pimozide)
- Pamelor (Nortriptyline)
- Paxil (Paroxetine)
- Prozac (Fluoxetine)
- Rexulti (Brexpiprazole)
- Risperdal (Risperidone)
- Seroquel (Quetiapine)
- Serzone (Nefazodone)
- Silenor (Doxepin)
- Tofranil (Imipramine)
- Trintellix (Vortioxetine)
- Vraylar (Cariprazine)
- Wellbutrin (Bupropion)
- Zoloft (Sertraline)
- Zyprexa (Olanzapine)
Attention Deficit / Hyperactivity Disorder
- Adderall ((Dextro)/Amphetamine)
- Strattera (Atomoxetine)
- Ritalin (Methylphenidate)
Anti-Anxiety
- Buspar (Buspirone)
- Klonopin (Clonazepam)
- Valium (Diazepam)
- Xanax (Alprazolam)
Order Your Test Now
- DNA Medication-Response Testing
- Patient-Specific Medication Report
- Facilitate Fast, Personalized Treatment